Her first lead role was in the 2003 film Love Don't Cost a Thing, and she subsequently had lead roles in Be Cool and the 2006 horror film Pulse.
Milian had a minor role in Ghosts of Girlfriends Past, and starred as the lead role in the straight-to-DVD film Bring It On: Fight to the Finish, training with former Cleveland Cavaliers dancer Kelly Wilson.
She always wanted to be in the record business, but did not know how to obtain a recording contract.
As a result, the album was again delayed until the first quarter of 2002; Milian believed that the public expected "a certain thing" from her when she first appeared with Ja Rule, however she wanted to record the type of music she was signed to do.
She said that "AM to PM" was a "cool record," but it was not what the public expected.
Milian has since been cast in the 2010 ABC Family Original Movie Christmas Cupid, alongside Ashley Benson and Chad Michael Murray.
I’m Cuban but [people] didn’t get it because I was also brown-skinned... You should see my mom and her brothers and sisters... But we’re still Latinos — that doesn’t change a damn thing.